The grouping will be according to the main therapeutic benefits at present assigned to fat cells. Those are:
Clearly the most relevant therapeutic benefit and the reason why, also seems to be clear. The harvest of regenerative cells from fat stems mainly, if not only, from the vasculature in fat tissue. Therefore their origin is from the vascúlar system, which is the reason why they are "native" to this human vascular system and feel "very comfortable" in places like the heart and the vascular system itself.
In view of the above and congruent to the theories of Caplan- the most potent regenerative cells- the Mesenchymal stem cells- tend to be attached in a pre-diffentiated state at the outer walls of the human vasculature system, ready to come to the rescue in case of injury with the secretion of trophic factors (cytokines which are growth factor molecules) capable of helping to regenerate all tissues and also all stages of regeneration or wound healing.
Auto-immune modulation including anti-inflammatory impact.
The same applies here as for wound healing with the additional benefit that on top of that the heterogeneous population of fresh cells contain cells that have a strong anti-inflammatory, immune modulation impact (the socalled Tregs) which are absent in the mix of cultured plastic-adherent differentiated MSC brews which are also used for therapeutic purposes.
An "Other" category which will likely include orthopedics, sports medicine and other stuff.
In view of the overall therapeutic benefits of fat cells this group is likely to become rather substantial and mixed. Key elements are likely to be the treatment of OA (Osteoarthritis) and tendon and muscle injuries.
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