Tidbits Blog

Fat Cell Tidbit Blog

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The Fat-cell Tidbit Blog is concipated to simply be a medium for spontaneous articles in respect of the science and applications of Fat Cells.

Anything that comes our way and seems important to share.

About Treating Addiction with Fat Cells

Addiction
Addiction

About treating addiction with fat cells and up-regulation of CXCR4 to improve homing

I was reading the blog of Dr. Joseph Purita yesterday (January 7th 2014), who reported recently about his trip to the Swiss clinic in Moscow and the discussions he had with Russian doctors at that clinic.  Highly interesting was his report that those doctors, besides treating addiction patients the traditional way, they also used fat cells for this purpose. From his blog: link here for whole article:
I was intrigued that they seemed to be having excellent success treating addiction problems by using mainly fat stem cells.Once the SVF is produced it is than treated with growth factors derived from platelet rich plasma (PRP).  What happens with the PRP is that it is clotted in a test tube.  Once the PRP is clotted it releases its growth factors.  The growth factors are mixed with the SVF and they are given intravenously.  Intravenous stem cells are used to treat a number of conditions including chronic obstructive pulmonary disease (COPD), diabetes, cardiac problems, neurological conditions and a variety of other conditions.  I spoke to the Russian doctors and they feel the stem cells travel to many parts of the body including the brain. This apparently helps with the addiction problems.  Their feeling is that addiction is a multi-faceted problem affecting many different portions of the body. One wrinkle that was done in Moscow was that we also used intravenous bone marrow aspirate.  As I have stated many times fat tissue has more mesenchymal stem cells while bone marrow has more hematopoietic stem cells.  The patient that was treated with IV SVF and bone marrow stem cells was a stroke patient.  He apparently had a good result from SVF alone so it was hoped that the combination would have an even better effect.

Read more: About Treating Addiction with Fat Cells

Fat Cells for Bone Growth?

Fatcells for Bone Growth?
Fatcells for Bone Growth?

During the past eight years I have been hearing and reading that those fat cells are rather stubborn, when it comes to differentiation to bone tissue. A simple explanation was always available when this stubbornness was compared to the virtues of MSCs from bone marrow in this respect.  This explanation was- well the source of the cells are fat and the cells much prefer to become adipose tissue again - their native source. For marrow sourced cells the obvious "target" tissue would be bone of course.  The main source of scientific information on work with ADRCs in respect of bone applications, the Vrije Universiteit in Amsterdam (Marco Helder et al) left however a lot to be hoped for, since they have been producing loads of papers on basic science and pre-clinical work, which all sounded very promising and yes- in 2012 they finally entered the clinic with a periondental application. Even more excitement was developed when the news broke that Basel University started a 270 patients clinic on shoulder fractures in elderly using fat cells. You do not start a large study like that if you do not have convincing reasons to do so- do you?

The explanation provided above about the stubbornness of ADRCs to (trans) differentiate to bone does not make much sense after learning about CaplanĀ“s theories that MSC pre-cursors basically all stem from the vascular system, but depending on source their chemistry to differentiate would be only slightly different. That is basically confirmed in a study presented below :

 

Read more: Fat Cells for Bone Growth?

Fat Chance: discovery of Muse-AT cells

Muse AT Cells
Muse AT Cells

In the summer of 2013 there were several "oddities"in respect of research on fat cells. Besides the already reported "ordinary fat cell cloning"- UCLA (the university characterizing the MSC-like virtues of plastic adherent fat cells first!) came out with a highly interesting announcement concerning socalled "MUSE- AT cells". I will just stay quiet here and let the article speak for itself.....

 

 

Researchers from the UCLA Department of Obstetrics and Gynecology have isolated a new population of primitive, stress-resistant human pluripotent stem cells that are easily derived from fat tissue and are able to differentiate into virtually every cell type in the human body without genetic modification.
The cells, called multi-lineage stress-enduring stem cells from adipose tissue (Muse-AT), were discovered by "scientific accident" when a piece of equipment failed in the laboratory, killing all the stem cells in an experiment except the Muse-AT cells.

 

Read more: Fat Chance: discovery of Muse-AT cells

A genuine oddity to start with

Cloning a cow from an
ning a cow from an "ordinary" fatcell

Since scientists of UCLA described and characterized regenerative cells from adipose tissue at first around the turn of the century, nothing much happened for about 7-8 years. After that timeframe, the trickle of reports on its potency and multiple "usable" mechanisms of therapeutic action in diverse applications started to accelerate and one can rightfully say at this point in time that "fat cells" are "in". 

Numerous researchers are publishing new "discoveries" in basic science and numerous medical clinicians-some working on a scientific basis- other not so much- are experimenting its use in the clinical setting.

To start off my blog, I thought it would be appropriate to have none of all that stuff, since I will be dealing with it on a regular basis. 

No - start with an oddity, which emphasizes that we are really still at the beginning of the development of "fat cells" and that there are still mysteries surrounding the science and the cells themselves.

For this purpose we turn to an article that originally appeared in the Latin American Herald Tribune- I found it amazing, that a calf can be cloned from an ordinary- well probably not so ordinary fat cell.

Enjoy and be amazed.....

 

Read more: A genuine oddity to start with